New England Journal of Medicine, Volume 366, Issue 10 (8 March 2012)
Language: English
Pages: 97
ISBN: 2:00093594
Format: PDF / Kindle (mobi) / ePub
Here We Go Again Another Failure of Postmarketing Device Surveillance R.G. Hauser (873-875)
Postmarketing Surveillance of Medical Devices Filling in the Gaps F.S. Resnic and S.-L.T. Normand (875-877)
Why Now Is Not the Time for Premium Support H.J. Aaron and A.B. Frakt (877-879)
The WydenRyan Proposal A Foundation for Realistic Medicare Reform J.R. Antos (879-881)
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing M. Gerlinger and Others (883-892)
Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease R. Howard and Others (893-903)
Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia M.P. Whyte and Others (904-913)
A 12-Month Phase 3 Study of Pasireotide in Cushing's Disease A. Colao and Others (914-924)
Brief Report: Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma M.A. Postow and Others (925-931)
Current Concepts: Dysfunction of the Diaphragm F.D. McCool and G.E. Tzelepis (932-942)
Ectopic Thyroid Gland M. Aalaa and M.R. Mohajeri-Tehrani (943)
Lingual Thyroid T.-Y. Yu and T.-C. Chang (e15)
Case 7-2012 A 79-Year-Old Man with Pain and Weakness in the Legs W.S. David, D.A. Chad, A. Kambadakone, and E.T. Hedley-Whyte (944-954)
Tumor Heterogeneity and Personalized Medicine D.L. Longo (956-957)
Discontinuing Donepezil or Starting Memantine for Alzheimer's Disease L.S. Schneider (957-959)
The Histone Code and Treatments for Acute Myeloid Leukemia L.A. Godley and M.M. Le Beau (960-961)
Regulatory T Cells in Graft-versus-Host Disease (962-963)
CPAP for Obstructive Sleep Apnea and the Metabolic Syndrome (963-966)
TFAP2E-DKK4 and Chemoresistance in Colorectal Cancer (966)
ICD Leads and Postmarketing Surveillance (967)
Germline JAK2 Mutation in a Family with Hereditary Thrombocytosis (967-969)
A Tale of Coronary Artery Disease and Myocardial Infarction (970)
Tourette's Syndrome (970)
A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures (970)
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Stephen Hawking: His Life and Work (Quest for Theory Everything)
Plant Physiology (5th Edition)
Temperament: How Music Became a Battleground for the Great Minds of Western Civilization
Fluid Mechanics of Flow Metering
chromosome 3p. Convergent evolution was observed for the X-chromosome–encoded histone H3K4 demethylase KDM5C, harboring disruptive mutations in R1 through R3, R5, and R8 through R9 (missense n engl j med 366;10 M2b R9 DI=1.43 DI=1.81 VHL SETD2 (missense) KDM5C (splice site) R4 M1 M2a Propidium Iodide Staining and frameshift deletion) and a splice-site mutation in the metastases (Fig. 2B and 2C). mTOR Functional Intratumor Heterogeneity The mammalian target of rapamycin (mTOR) kinase
of phenotypic tumor-cell diversity. Genomics analyses from single tumor-biopsy specimens may underestimate the mutational burden of heterogeneous tumors. Intratumor heterogeneity may explain the difficulties encountered in the validation of oncology biomarkers owing to sampling bias,29 contribute to Darwinian selection of preexisting drug-resistant clones,12,30 and predict therapeutic resistance.13 Reconstructing tumor clonal architectures and the identification of common mutations located in the
maximal expiratory pressure (70 to 80% of the predicted value) may simply reflect suboptimal length–tension properties of the expiratory muscles at a restricted total lung capacity, rather than a generalized myopathic process. Direct measures of diaphragmatic function can be classified as invasive (e.g., transdiaphragmatic pressure [Pdi]) or noninvasive (e.g., ultrasonography). These tests may not be offered at some institutions but may be required when the diagnosis remains uncertain.
progress, despite discontinuation of the statin.7,8 Muscle-biopsy specimens from such patients show muscle necrosis but not inflammation, and the patients may respond to intensive immunosuppressive therapy, favoring an immune-mediated mechanism triggered by statins. Recently, autoantibodies against HMG-CoA reductase7,9 have been described in such patients; these autoantibodies were not found in asymptomatic statin users or in patients with statin-associated myalgias. If subsequent studies show a
conference; and Drs. Aida Kuri, Donald Bloch, Sebastian Unizony, and Lloyd Axelrod for assisting in the preparation of the case history. REFERENCES 1. García-Rodríguez LA, Massó-González EL, Wallander MA, Johansson S. The safety of rosuvastatin in comparison with other statins in over 100,000 statin users in UK primary care. Pharmacoepidemiol Drug Saf 2008;17:943-52. 2. García-Rodríguez LA, González-Pérez A, Stang MR, Wallander MA, Johansson S. The safety of rosuvastatin in comparison with