The Mysterious World of the Human Genome
Frank Ryan
Language: English
Pages: 300
ISBN: 1633881520
Format: PDF / Kindle (mobi) / ePub
The human genome is indeed a mysterious world, but, as this fascinating book shows, its vital secrets are now being uncovered. The latest studies are revealing exciting new discoveries, such as how the DNA and related chemical compounds in our cells work together to direct the processes of life. Scientists are not only unraveling how life evolved in the ancient past, but are also finding the keys to creating a healthier future.
How does the minuscule chemical cluster in each of our 100 trillion cells accomplish the amazing feat of creating and maintaining our bodies? Frank Ryan, a physician and an evolutionary biologist, describes the complex ways in which the genome operates as a holistic system and not solely through genes coding for proteins—the building blocks of life. Also involved are elaborate switching mechanisms that regulate and control portions of our DNA, as well as the interplay of retroviruses and bacteria.
This groundbreaking book explains that we are on the cusp of an amazing era of disease treatment and eradication.
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siblings, other than identical twins, but even siblings would show some differences as a result of sexual homologous recombination. In the jargon, these sites were locations of “variable number of tandem repeats,” or VNTR. What Jeffreys did next was to develop a simple methodology based on the numbers of repeats at ten different VNTR locations scattered throughout the chromosomes. Why ten? We might indulge in the same simple mathematics we used earlier to determine how many nucleotides we needed
rebuffed cooperation with Wilkins, the King's group had eschewed the opportunity of taking up the Pauling-inspired modeling approach. And now, at what must have appeared a critical moment in time, what were Crick and Watson to make of the fact that Franklin was leaving King's, abandoning her work on the DNA fiber, and at the same time Wilkins had also stopped working on DNA, waiting, as he confessed, for the dust of Franklin's departure to settle before vaguely starting anew. Watson had every
the body of the “female” bacterium. While bacterial reproduction by budding took only twenty minutes, bacterial sex lasted for roughly two hours. This allowed Jacob and Wollman to conduct a series of “coitus interruptus” experiments in which they halted the process at timed intervals along the two-hour process. Since the bacterial chromosome always came through in the same order of genes, they could, through looking for the effects of specific mutated genes, plot where along the course of the
notorious infections were everyday threats, including tuberculosis, which ravaged entire families; or boils; septic arthritis; septic osteomyelitis, which caused agonizing abscesses in bone; and the commonplace but potentially deadly streptococci capable of breaking through a septic throat to cause abscesses in the brain. Most of the human population, whether in developed or developing countries, died from infections, including the insidious pneumonias that hit those whose immunity was depressed.
movements, but I should add that, as we might expect from historic sources, they also show huge population mixing. Curiously, when we look at the matrilineal-based mitochondrial haplogroups in Europe, we see what appears to be a very different pattern from what we saw in the male-associated Y chromosome. When compared to the males, the female-associated haplogroups show much less geographic patterning, which seems to indicate that European women share a more common ancestry. How fascinating if